Iodine → (E)-3-cyclopentyl-2-iodo-acrylic acid methyl ester

Temperature

25 °C

A mixture of lithium chloride (8.48 g, 209 mmol, predried at 130° C. under high vacuum for 3 h) and copper cyanide (8.96 g, 100 mmol) in dry tetrahydrofuran (100 mL) was stirred at 25° C. under argon for 10 min to obtain a clear solution. The reaction mixture was then cooled to −70° C. and then slowly treated with a 2.0M solution of cyclopentylmagnesium chloride in diethyl ether (55 mL, 110 mmol). After the addition, the reaction mixture was allowed to warm to −30° C. where it was stirred for 5 min. The resulting reaction mixture was again cooled back to −70° C. and then slowly treated with methyl propiolate (7.99 g, 95 mmol). The reaction mixture was stirred overnight at −60° C. to −50° C. The reaction mixture was then slowly treated with a solution of iodine (34.3 g, 135 mmol) in dry tetrahydrofuran (30 mL), with the temperature kept at −70° C. to −60° C. After addition of the iodine solution, the cooling bath was removed, and the reaction mixture was allowed to warm to 25° C. where it was stirred for 2 h. The reaction mixture was then poured into a solution consisting of a saturated aqueous ammonium chloride solution (200 mL) and ammonium hydroxide (50 mL), and the organic compound was extracted into diethyl ether (3×100 mL). The combined organic extracts were successively washed with a saturated aqueous sodium thiosulfate solution (1×300 mL) and a saturated aqueous sodium chloride solution (1×300 mL). The organic layer was then dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 20/1 hexanes/diethyl ether) afforded (E)-3-cyclopentyl-2-iodo-acrylic acid methyl ester (25.8 g, 97%) as a yellow oil: EI-HRMS m/e calcd for C9H13IO2 (M+) 279.9960, found 279.9961.

1. customto obtain a clear solution
2. temperatureThe reaction mixture was then cooled to −70° C.
3. additionAfter the addition
4. temperatureto warm to −30° C. where it
5. stirringwas stirred for 5 min
6. customThe resulting reaction mixture
7. temperaturewas again cooled back to −70° C.
8. stirringThe reaction mixture was stirred overnight at −60° C. to −50° C
9. customkept at −70° C. to −60° C
10. customthe cooling bath was removed
11. temperatureto warm to 25° C. where it
12. stirringwas stirred for 2 h
13. additionThe reaction mixture was then poured into a solution
14. extractionthe organic compound was extracted into diethyl ether (3×100 mL)
15. washThe combined organic extracts were successively washed with a saturated aqueous sodium thiosulfate solution (1×300 mL)
16. dry with materialThe organic layer was then dried over anhydrous magnesium sulfate
17. filtrationfiltered
18. concentrationconcentrated in vacuo

ORD record

ord-25115a1f96f94553a6ca4d43ac7ce5fd

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06369232B1