Potassium Carbonate → HCID 22568978, compound

HRID 841414Notes

Reaction equation

HRID 841414 reaction equation
COC(=O)CC1C=CC([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3([O:22][CH2:23][C:24]4C=CC=CC=4)[CH2:21][CH2:20]3)=[C:15]([CH3:30])[CH:14]=2)=CC=1.[C:32](=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([O:22][CH:23]([CH3:24])[CH3:32])[CH2:20][CH2:21]2)=[C:15]([CH3:30])[CH:14]=1)#[CH:11]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86585924Methyl{4-[4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-phenyl}-acetate2×

Product 1

HCID 22568978HCID 22568978, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 80, 250.0 mg, 0.87 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (180 mg, 98%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-b4ae9f804319406ea2c48725581732ba
Source dataset
uspto-grants-2002_04
Patent number
US06369225B1

Reaction notes

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