HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chloroform → (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-N-octyl-methane-sulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chloroform | HCID 6212 | — |
| Edukt | Octylamine | HCID 8143 | — |
| Edukt | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl-methanesulfonyl)-piperidine-4-carboxylic acid methyl ester | HCID 12138183 | — |
| Edukt | (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chloride | HCID 12138193 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-N-octyl-methane-sulfonamide | HCID 12138195 | 69% |
Reaktionsschritte
(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-N-octyl-methane-sulfonamide (21) is prepared similarly to compound (10) from compound (19) and n-octylamine in dry acetonitrile. It is isolated by column chromatography on silica gel using a gradient running from chloroform to ethanol.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846924B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-c485fc9fd69d447d9cb1396e391677a2 |
| Quellennotiz | uspto-grants-2014_09 |