Potassium Carbonate → HCID 18710218, compound

HRID 841515Notes

Reaction equation

HRID 841515 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:16]#[C:17][Si](C)(C)C)[CH:7]=[CH:8][C:9]=1[CH2:10][O:11][C:12]1([CH3:15])[CH2:14][CH2:13]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:16]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][O:11][C:12]2([CH3:15])[CH2:13][CH2:14]2)=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=1)#[CH:17]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69548710[3-Isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane2×

Product 1

HCID 18710218HCID 18710218, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [3-isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane (Intermediate 165, 110.0 mg, 0.37 mmol) in methanol (6 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne (84 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-e04e3abce8b44d5186f0edabb34e4816
Source dataset
uspto-grants-2002_04
Patent number
US06369225B1

Reaction notes

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