Potassium Carbonate → HCID 22568978, compound

HRID 841658Notes

Reaction equation

HRID 841658 reaction equation
COC(=O)CC1C=CC([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3([O:22][CH2:23][C:24]4C=CC=CC=4)[CH2:21][CH2:20]3)=[C:15]([CH3:30])[CH:14]=2)=CC=1.[C:32](=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([O:22][CH:23]([CH3:24])[CH3:32])[CH2:20][CH2:21]2)=[C:15]([CH3:30])[CH:14]=1)#[CH:11]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86585924Methyl{4-[4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-phenyl}-acetate2×

Product 1

HCID 22568978HCID 22568978, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 80, 250.0 mg, 0.87 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (180 mg, 98%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-2517c8bd93e34a249ded5eeb8c066113
Source dataset
uspto-grants-2002_04
Patent number
US06369261B1

Reaction notes

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