反应详情

Compound 10 is prepared using synthesis method 2: intermediate 3b (0.16 g, 0.67 mmol) is placed in 21 mL of acetonitrile in the presence of 0.18 g (0.67 mmol) of intermediate 5a and 103 μL of Et3N. 0.21 g (0.67 mmol) of TBTU is then added and the mixture is then stirred for 5 h at ambient temperature. After evaporation under reduced pressure the residue is taken up by water and extracted using AcOEt. After the organic phases are dried and after reduction to dryness the residue obtained is purified by flash chromatography (CH2Cl2-MeOH, gradient 99-1 to 95-5 over 65 min). 0.23 g of solid is obtained (yield: 68%).

1. customsynthesis method 2
2. customAfter evaporation under reduced pressure the residue
3. extractionextracted
4. customAfter the organic phases are dried
5. customafter reduction to dryness the residue obtained
6. customis purified by flash chromatography (CH2Cl2-MeOH, gradient 99-1 to 95-5 over 65 min)