Potassium Carbonate → 4-Ethynyl-1-(1-isopropoxycyclopropyl)-2-ethyl-benzene

HRID 841674Notes

Reaction equation

HRID 841674 reaction equation
[CH:1]([O:4][C:5]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][C:9]=2[CH2:20][CH3:21])[CH2:7][CH2:6]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2([O:4][CH:1]([CH3:2])[CH3:3])[CH2:6][CH2:7]2)=[C:9]([CH2:20][CH3:21])[CH:10]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568952HCID 22568952, compound2×

Product 1

HCID 225688574-Ethynyl-1-(1-isopropoxycyclopropyl)-2-ethyl-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane (Intermediate 94, 330.0 mg, 1.10 mmols) in methanol (10 mL) was treated with potassium carbonate (150.0 mg, 1.10 mmol) and stirred overnight at ambient temperature. The crude alkyne (238 mg, 95%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-b865e0c71b794546883bdd1c5ae3eeac
Source dataset
uspto-grants-2002_04
Patent number
US06369261B1

Reaction notes

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