Hydrochloric Acid → 2-(4-{6-[2-(2-Fluoro-phenyl)-pyridin-4-yl]-pyrazin-2-yl}-pyrazol-1-yl)-ethanol

Participants

Reaction Steps

680 mg of the above prepared 2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine are dissolved in 12 ml dioxane. 1.1 l of HCl in dioxane (4 mol/l) is added. The product precipitates from the solution and is filtered. 147 mg of 2-(4-{6-[2-(2-fluoro-phenyl)-pyridin-4-yl]-pyrazin-2-yl}-pyrazol-1-yl)-ethanol are obtained.

Provenance & Evidence