Hydrochloric Acid → 2-(4-{6-[2-(2-Fluoro-phenyl)-pyridin-4-yl]-pyrazin-2-yl}-pyrazol-1-yl)-ethanol

HRID 84176Notes

Reaction equation

HRID 84176 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]2[CH:19]=[N:18][CH:17]=[C:16]([C:20]3[CH:21]=[N:22][N:23]([CH2:25][CH2:26][O:27]C4CCCCO4)[CH:24]=3)[N:15]=2)[CH:11]=[CH:10][N:9]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]2[N:15]=[C:16]([C:20]3[CH:21]=[N:22][N:23]([CH2:25][CH2:26][OH:27])[CH:24]=3)[CH:17]=[N:18][CH:19]=2)[CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66652885HCID 66652885, compound

Product 1

HCID 565977532-(4-{6-[2-(2-Fluoro-phenyl)-pyridin-4-yl]-pyrazin-2-yl}-pyrazol-1-yl)-ethanol

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

680 mg of the above prepared 2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine are dissolved in 12 ml dioxane. 1.1 l of HCl in dioxane (4 mol/l) is added. The product precipitates from the solution and is filtered. 147 mg of 2-(4-{6-[2-(2-fluoro-phenyl)-pyridin-4-yl]-pyrazin-2-yl}-pyrazol-1-yl)-ethanol are obtained.

Workup

  1. customThe product precipitates from the solution
  2. filtrationis filtered

Sources & evidence

ORD record
ord-0724f4e612414eda9b803beb80fb4459
Source dataset
uspto-grants-2014_09
Patent number
US08846931B2

Reaction notes

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