Tetrahydrofuran → HCID 15434277, compound

HRID 841915Notes

Reaction equation

HRID 841915 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([OH:12])=O.C1COCC1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][N:23]=[C:22]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[N:21]=1>O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([N:29]1[CH2:30][CH2:31][N:26]([C:22]2[N:21]=[C:20]([O:19][CH3:18])[CH:25]=[CH:24][N:23]=2)[CH2:27][CH2:28]1)=[O:12]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 72899Indole-2-carboxylic acidHCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidine

Product 1

HCID 15434277HCID 15434277, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.83 g (5.15 mmol) of indol-2-carboxylic acid in 15 mL of dry THF 0.83 g (5.15 mmol) of N,N′-carbonyldiimidazol is added. After 30 minutes 1.0 g (5.15 mmol) of 4 methoxy-2-(1-piperazinyl) pyrimidine is added to the solution and it is left overnight with continuous stirring. The solvent is eliminated under reduced pressure and H2O added. This produces a precipitate which is filtered and dried, to give 1.7 g (5.04 mmol) of 2-[4-(2-indolylcarbonyl)-1-piperazinyl]-4-methoxypyrimidine. m.p.=202-203° C.

Workup

  1. additionadded
  2. customThis produces a precipitate which
  3. filtrationis filtered
  4. customdried

Sources & evidence

ORD record
ord-8f81b465fa4840d2ac4c88d8eaaadab7
Source dataset
uspto-grants-2002_04
Patent number
US06372746B1

Reaction notes

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