反应详情

Aqueous lithium hydroxide (1N, 51 ml) was added to a solution of methyl (2S)-1-(1,3-benzoxazol-2-yl)-2-piperidinecarboxylate (8.987 g) [see Preparation 2] in methanol (306 ml) at 0° C. The reaction mixture was stirred at room temperature for 18 hours, after which time the solvent was removed under reduced pressure and the residue partitioned between ethyl acetate and water. The aqueous layer was separated and acidified to pH 2 with 2N aqueous hydrochloric acid, the product was extracted with ethyl acetate, dried over magnesium sulphate and the solvent removed under reduced pressure to afford (2S)-1-(1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid (8.17 g) as a white solid.

1. customafter which time the solvent was removed under reduced pressure
2. customthe residue partitioned between ethyl acetate and water
3. customThe aqueous layer was separated
4. extractionthe product was extracted with ethyl acetate
5. dry with materialdried over magnesium sulphate
6. customthe solvent removed under reduced pressure