Lithium Hydroxide → (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid

HRID 841946Notes

Reaction equation

[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]3[C:15]([O:17]CC)=[O:16])[S:8][C:4]=2[CH:3]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]3[C:15]([OH:17])=[O:16])[S:8][C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 57293748ethyl (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylate

Product 1

HCID 57113159(2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid

Procedure

The title compound was prepared by a similar method to Preparation 3 from ethyl (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylate [see Preparation 44] and 1N aqueous lithium hydroxide solution to afford (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid as a solid.

Sources & evidence

ORD record: ord-dcef57de036e4707b401816ca312b60e
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06372736B1

Reaction notes

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