Chloroacetic Acid → HCID 178515561, compound

HRID 841980Notes

Reaction equation

HRID 841980 reaction equation
S[C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.ClCC(O)=[O:18].Cl>O>[OH:18][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

Participants

5

Reactant 3

HCID 300Chloroacetic AcidHCID 313Hydrochloric AcidHCID 178515562HCID 178515562, compound

Product 1

HCID 178515561HCID 178515561, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Mercapto-4-hydroxy-6-phenylpyrimidine (8.6 g, 42 mmol) and chloroacetic acid (8.5 g, 90 mmol) were slurried in water (100 mL). After refluxing the mixture for 24 hours, hydrochloric acid was added and the precipitate was isolated by filtration. The solid was dried in a vacuum oven to give 6.6 g (83%) of 2,4-dihydroxy-6-phenylpyrimidine.

Workup

  1. temperatureAfter refluxing the mixture for 24 hours
  2. customthe precipitate was isolated by filtration
  3. customThe solid was dried in a vacuum oven

Sources & evidence

ORD record
ord-a6ff949987924cea92a2fc2f9ac92680
Source dataset
uspto-grants-2002_04
Patent number
US06372751B1

Reaction notes

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