反应详情

温度

130 °C

Dissolve 5-amino-4-(4-chloro-2,6-dimethylphenyl)-3-methylpyrazole in 20 mL glacial acetic acid at ambient temperature, and add ethyl acetoacetate (2.0 mL, 1.99 g). Heat to reflux (130° C.) under N2 overnight. Evaporate down to concentrate and add 200 mL Et2O to precipitate out product. Stir at ambient temperature for 1 hour, then filter and wash the resulting white solid (1.25 g) with copious amounts of Et2O. LCMS=302.2 (MH+); 300.2 (M−).

1. temperatureHeat
2. customEvaporate down
3. concentrationto concentrate
4. additionadd 200 mL Et2O
5. customto precipitate out product
6. filtrationfilter
7. washwash the resulting white solid (1.25 g) with copious amounts of Et2O