HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22617796, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | HCID 15462528 | HCID 15462528 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22617796 | HCID 22617796 | 85.1% |
Reaction Steps
A mixture of 8,9-dihydro-9-methyl-8-oxo-2-phenyl-7H-purin-7-acetic acid (9.1 g) obtained in Example 48-(2), methylamine hydrochloride (3.2 g), BOP reagent (21.2 g), triethylamine (9.7 g), and dimethylformamide (100 ml) is stirred at room temperature for two hours. Water is added to the reaction mixture, and the precipitates are collected by filtration, and washed with water to give crude 8,9-dihydro-9-methyl-N-methyl-8-oxo-2-phenyl-7H-purin-7-acetamide (8.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372740B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-c34988198674447f86112e9b274cc897 |
| Source note | uspto-grants-2002_04 |