Triethylamine → HCID 22617796, compound

HRID 842069Notes

Reaction equation

HRID 842069 reaction equation
[CH3:1][N:2]1[C:10](=[O:11])[N:9]([CH2:12][C:13](O)=[O:14])[C:8]2[C:3]1=[N:4][C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][CH:7]=2.Cl.CN.[CH3:25][N:26]([P+](ON1N=NC2C=CC=CC1=2)(N(C)C)N(C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)CC)C>O.CN(C)C=O>[CH3:1][N:2]1[C:10](=[O:11])[N:9]([CH2:12][C:13]([NH:26][CH3:25])=[O:14])[C:8]2[C:3]1=[N:4][C:5]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[N:6][CH:7]=2

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 6364545Methylamine hydrochlorideHCID 15462528HCID 15462528, compound

Product 1

HCID 22617796HCID 22617796, compoundYield 85.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 8,9-dihydro-9-methyl-8-oxo-2-phenyl-7H-purin-7-acetic acid (9.1 g) obtained in Example 48-(2), methylamine hydrochloride (3.2 g), BOP reagent (21.2 g), triethylamine (9.7 g), and dimethylformamide (100 ml) is stirred at room temperature for two hours. Water is added to the reaction mixture, and the precipitates are collected by filtration, and washed with water to give crude 8,9-dihydro-9-methyl-N-methyl-8-oxo-2-phenyl-7H-purin-7-acetamide (8.1 g).

Workup

  1. filtrationthe precipitates are collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-c34988198674447f86112e9b274cc897
Source dataset
uspto-grants-2002_04
Patent number
US06372740B1

Reaction notes

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