反应详情

m-Fluoroaniline (5 mmol, 0.6 g), 3-oxo-2-(2-oxo-2-phenyl-ethyl)-butyric acid ethyl ester (5 mmol, 1.2 g), and tosic acid were combined in ethanol, then heated under reflux. The resulting solid was resuspended in chloroform, then washed with water, 5% sodium bicarbonate, and brine. The organic layer was dried over NaSO4, then the solids were separated and the solvents removed under vacuum. The named product was recrystallized from ethanol (m.p. 96.3° C.-98.0° C.).

1. temperatureheated
2. temperatureunder reflux
3. washwashed with water, 5% sodium bicarbonate, and brine
4. dry with materialThe organic layer was dried over NaSO4
5. customthe solids were separated
6. customthe solvents removed under vacuum
7. customThe named product was recrystallized from ethanol (m.p. 96.3° C.-98.0° C.)