Hydrochloric Acid → 2-Amino-4-(4-octylphenyl)butanoic acid hydrochloride

HRID 842262Notes

Reaction equation

HRID 842262 reaction equation
C([NH:4][C:5]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:20][CH:19]=1)(C(OCC)=O)[C:6]([O:8]CC)=[O:7])(=O)C.[ClH:32]>C(O)C>[ClH:32].[NH2:4][CH:5]([CH2:16][CH2:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:22][CH:23]=1)[C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 98457531,3-Diethyl 2-(acetylamino)-2-(2-(4-octylphenyl)ethyl)propanedioate

Product 1

HCID 701487132-Amino-4-(4-octylphenyl)butanoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate (20 g) was added to a 5N aqueous hydrochloric acid solution (350 ml) and the mixture was refluxed under heating for 6.5 hours. Ethanol (45 ml) was added to the mixture and the whole mixture was further refluxed under heating for 1.5 hours. The reaction mixture was concentrated under reduced pressure to give the subject compound (20 g).

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 6.5 hours
  3. temperaturethe whole mixture was further refluxed
  4. temperatureunder heating for 1.5 hours
  5. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-27fe86107dcc41c8ad675a8900175c4b
Source dataset
uspto-grants-2002_04
Patent number
US06372800B1

Reaction notes

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