Diethyl methylmalonate → Diethyl 2-(2-(2-benzyloxyphenyl)ethyl)-2-methylmalonate

HRID 842273Notes

Reaction equation

HRID 842273 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:7])=[O:5].[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28]I)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28][C:6]([CH3:7])([C:4]([O:3][CH2:2][CH3:1])=[O:5])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 11857Diethyl methylmalonateHCID 226187172-(2-Benzyloxyphenyl)ethyl iodide

Product 1

HCID 22618873Diethyl 2-(2-(2-benzyloxyphenyl)ethyl)-2-methylmalonate

Procedure

2-Methylmalonic acid diethyl eater and 2-(2-benzyloxyphenyl)ethyl iodide were used in the same manner as working example 52 (S) to give the subject compound.

Workup

  1. customto give the subject compound

Sources & evidence

ORD record
ord-e20db442b6b2485e9a0f15ea1522f38d
Source dataset
uspto-grants-2002_04
Patent number
US06372800B1

Reaction notes

Loading…