Sodium Bicarbonate → Benzylamide tetrasodium salt

HRID 842352Notes

Reaction equation

HRID 842352 reaction equation
[CH2:1]([NH-:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+:13]>O1CCOCC1>[Na+:13].[Na+:13].[Na+:13].[Na+:13].[CH2:1]([NH-:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([NH-:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([NH-:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([NH-:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22619318Benzyl amide

Product 1

HCID 86757958Benzylamide tetrasodium salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Subsequently, to the above benzylamide of S1 anhydride (157 mg) were added a sodium bicarbonate aqueous solution (NaHCO3 110 mg, water 20 mL) and 1,4-dioxane (20 mL), and the resultant was allowed to undergo a reaction at room temperature for 16 hours. After the reaction was completed, the solvent was removed under reduced pressure to afford benzylamide tetrasodium salt of S1 compound (196 mg). The 1H-NMR and IR data of this compound were as shown below. From these data, the compound thus obtained was confirmed to be a derivative in which the carboxyl groups bonded t the saturated carbon atoms in the structural formula S1 compound were benzylamidated) while other carboxyl groups were substituted with sodium salt.

Workup

  1. customa reaction at room temperature for 16 hours
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-46a7c8b5e41d4f04b971fe04ee4b9ef1
Source dataset
uspto-grants-2002_04
Patent number
US06372943B1

Reaction notes

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