反应详情

(2R)-4-{4-[2-fluoro-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2-oxopyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (335 mg, 0.58 mmol) was dissolved in 3 mL of dioxane. To this solution was added 1 mL of 4M HCl in dioxane 1 mL of water. The resulting solution was stirred at RT for 10 minutes. The material was diluted up with methanol and concentrated (3×). Dichloromethane was added and the mixture was stirred for 18 h. The solution retained color and a fine particulate was suspended. The mixture was filtered leaving 13.3 mg (6%) of white solid. LCMS m/z 413.6 (M+1) 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.71 (s, 3 H) 2.14 (d, J=1.56 Hz, 3 H) 2.33-2.46 (m, 1 H) 2.54-2.68 (m, 1 H) 3.10 (s, 3 H) 3.91-4.05 (m, 1 H) 4.24-4.40 (m, 1 H) 6.70 (d, J=8.59 Hz, 1 H) 6.75-6.86 (m, 2 H) 7.23 (t, J=8.68 Hz, 1 H) 7.75 (d, J=6.83 Hz, 1 H)

1. concentrationconcentrated (3×)
2. additionDichloromethane was added
3. stirringthe mixture was stirred for 18 h
4. filtrationThe mixture was filtered