Acetic Acid → HCID 11404582, compound

HRID 842539Notes

Reaction equation

HRID 842539 reaction equation
[NH2:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH3:12])[CH:9]=2)[CH:4]=[CH:3]1.CN(C)[C:15]1[O:16][C:17](=[O:25])[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:20]=1.C(O)(=O)C>O>[CH3:12][O:11][C:8]1[CH:9]=[C:10]2[C:5]([CH:4]=[CH:3][N:2]2[N:1]2[C:17](=[O:25])[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[NH:20][C:15]2=[O:16])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 37238622-(dimethylamino)-4-(trifluoromethyl)-6H-1,3-oxazin-6-oneHCID 11816030HCID 11816030, compound

Product 1

HCID 11404582HCID 11404582, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 0.2 g 1A, 0.268 g 2-dimethylamino-4-trifluoromethyl-1,3-oxazin-6-one (obtained according to M.-A. Decock-Plancquaert et al., Bull. Soc. Chim. Belg. 101 (4) 313-321 (1992)) and 10 ml acetic acid is refluxed for 4 hours. The mixture is poured into water, extracted and chromatographed to yield 0.23 g of 1B as an oil.

Workup

  1. temperatureis refluxed for 4 hours
  2. extractionextracted
  3. customchromatographed

Sources & evidence

ORD record
ord-85098c0d155b4819aa2813af14cfe560
Source dataset
uspto-grants-2002_04
Patent number
US06376426B1

Reaction notes

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