Methyl iodide → HCID 22614256, compound

HRID 842546Notes

Reaction equation

HRID 842546 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[N:11]1[C:16](=[O:17])[CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[NH:13][C:12]1=[O:22].[C:23](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[N:11]1[C:16](=[O:17])[CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[N:13]([CH3:23])[C:12]1=[O:22]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 22614259HCID 22614259, compound

Product 1

HCID 22614256HCID 22614256, compoundYield 24.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 169B (0.88 g, 2.7 mmol), dry acetonitril (10 mL), potassium carbonate (0.41 g, 2.9 mmol) and methyl iodide (0.88 g, 6.2 mmol) is stirred overnight at room temperature. The solids are removed by filtration. The motherliquor is concentrated under reduced pressure. The residue obtained is purified by flash chromatography (ethyl acetate/petrol ether 2/8) to yield the product as a brown oil (0.23 g).

Workup

  1. customThe solids are removed by filtration
  2. concentrationThe motherliquor is concentrated under reduced pressure
  3. customThe residue obtained
  4. customis purified by flash chromatography (ethyl acetate/petrol ether 2/8)

Sources & evidence

ORD record
ord-99e29f8607a7475487b393438ca9d412
Source dataset
uspto-grants-2002_04
Patent number
US06376426B1

Reaction notes

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