反应详情

30.5 g of paraformaldehyde are added, at room temperature, to a mixture of 20 g of N-methyl-N′-nitroguanidine, 17 g of triethylamine, 100 ml of dioxane and 100 ml of toluene, and the mixture is refluxed for 16 hours and subsequently evaporated in vacuo. The residue is purified by column chromatography [silica gel; dichloromethane/methanol (95:5)], giving the tide compound which melts at 137 to 139°.

1. temperaturethe mixture is refluxed for 16 hours
2. customsubsequently evaporated in vacuo
3. customThe residue is purified by column chromatography [silica gel; dichloromethane/methanol (95:5)]
4. customgiving the tide compound which melts at 137 to 139°