HCID 22614804, compound → HCID 22614829, compound

HRID 842619Notes

Reaction equation

HRID 842619 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:13][CH:10]3[CH2:11][O:12][C:7]=2[CH:6]=[CH:5][CH:4]=1.[Cl:22][C:23]1[N:24]=[C:25]2[C:31]([N:32]=[C:33]=[O:34])=[C:30]([C:35](OCC)=[O:36])[S:29][C:26]2=[N:27][CH:28]=1>>[ClH:22].[ClH:22].[CH3:1][O:2][C:3]1[C:8]2[N:9]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]4[C:35](=[O:36])[C:30]5[S:29][C:26]6[N:27]=[CH:28][C:23]([Cl:22])=[N:24][C:25]=6[C:31]=5[NH:32][C:33]4=[O:34])[CH2:13][CH:10]3[CH2:11][O:12][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 22614804HCID 22614804, compoundHCID 22614820HCID 22614820, compound

Product 1

HCID 22614829HCID 22614829, compound

Procedure

The product from Example 11A and the product from Example 8D were processed as described in Example 1L to provide the title compound. mp 198-201° C.; [α]23D−7.8 °(c 1.02, DMSO); 1H NMR (300 MHz, DMSO-d6) δ1.60-1.85 (m, 4H), 2.80-3.75 (m, 7H), 3.78 (s,3H), 3.82-4.75 (m, 6H), 6.42-6.95 (m, 3H), 9.02 (s, 1H), 10.60 (bs, 1H), 1290 (s, 1H); MS (DCI/NH3) m/e 529 (M+H)+; Anal. calcd for C24H25N6O4SCl.2.0 HCl: C, 47.89; H, 4.52; N, 13.96. Found: C, 47.64; H, 4.62; N, 13.63.

Sources & evidence

ORD record
ord-fc6dbab07c7140838b61fafdc0020851
Source dataset
uspto-grants-2002_04
Patent number
US06376488B1

Reaction notes

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