反应详情

3.2 g of 98 in 50 ml of methylene chloride/methanol 1:1 is dissolved, and 750 mg of p-toluenesulfonic acid is added. It is stirred under argon for 2 hours at room temperature. Sodium chloride solution is added, extracted with methylene chloride, the organic phase is washed with sodium bicarbonate solution and sodium chloride-solution, dried on sodium sulfate and concentrated by evaporation. The residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 2.7 g of 1-[1-(1-hydroxy-2,2,3,3,4,4,5,5,5-nonafluoropentyl)cyclopropyl]ethanone 99 is obtained as a colorless oil.

1. extractionextracted with methylene chloride
2. washthe organic phase is washed with sodium bicarbonate solution and sodium chloride-solution
3. customdried on sodium sulfate
4. concentrationconcentrated by evaporation
5. customThe residue is chromatographed on silica gel with ethyl acetate/hexane