反应详情

A mixture of 6,7-dichloro-2,3-dimethoxy-5-(4-pyridyl)quinoxaline (Preparation 2, 110 mg, 0.327 mmol), 2M aqueous hydrochloric acid solution (1 mL) and 1,4-dioxane (7 ml) was heated under reflux for 2 hours, cooled, and concentrated under reduced pressure. The solid residue was triturated with water, collected by filtration and washed with water and diethyl ether to give the title compound (17 mg, 17%) as a white solid, mp >300° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. temperaturecooled
4. concentrationconcentrated under reduced pressure
5. customThe solid residue was triturated with water
6. filtrationcollected by filtration
7. washwashed with water and diethyl ether