Dimethylformamide dimethyl acetal → HCID 18726768, compound

HRID 842672Notes

Reaction equation

HRID 842672 reaction equation
[Cl:1][C:2]1[C:11]([Cl:12])=[CH:10][C:9]2[N:8]=[C:7]([O:13][CH3:14])[C:6]([O:15][CH3:16])=[N:5][C:4]=2[C:3]=1[C:17]([NH2:19])=[O:18].CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>>[CH3:22][N:23]([CH3:25])[CH:24]=[N:19][C:17]([C:3]1[C:2]([Cl:1])=[C:11]([Cl:12])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:15][CH3:16])[C:7]([O:13][CH3:14])=[N:8]2)=[O:18]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 22614903HCID 22614903, compound

Product 1

HCID 18726768HCID 18726768, compoundYield 92%

Procedure

6,7-Dichloro-2,3-dimethoxyquinoxaline-5-carboxamide (Preparation 24, 1.96 g, 6.49 mmol) in N,N-dimethylformamide dimethyl acetal (25 mL) was heated under reflux for 2 hours. After being cooled the mixture was concentrated under reduced pressure and the residue triturated with diethyl ether to afford N1,N1-dimethyl-N2-[6,7-dichloro-2,3-dimethoxyquinoxalin-5-ylcarbonyl]formamidine (2.14 g, 92%) as a pale yellow solid.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter being cooled the mixture
  3. concentrationwas concentrated under reduced pressure
  4. customthe residue triturated with diethyl ether

Sources & evidence

ORD record
ord-bd51f96dedae4ab6822652aee134a038
Source dataset
uspto-grants-2002_04
Patent number
US06376490B1

Reaction notes

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