反应详情

A mixture of pyrimidine-2-carboxylic acid ethyl ester (Ann. Chim., 5, 351 (1960)) (0.866 g, 5.7 mmol) and hydrazine hydrate (0.332 mL, 6.8 mmol) in ethanol (20 mL) was heated under reflux for 3 hours, then concentrated under reduced pressure. The residue was triturated with diethyl ether, collected by filtration and washed with ethyl acetate to give the title compound (0.542 g, 69%) as a yellow solid, mp 173-175° C.

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. concentrationconcentrated under reduced pressure
4. customThe residue was triturated with diethyl ether
5. filtrationcollected by filtration
6. washwashed with ethyl acetate