反应详情

温度

50 °C

A mixture of 2-chloro-6-chloromethyl-3-cyanopyridine (600 mg, 3.21 mmol) and sodium azide (229 mg, 3.53 mmol) in DMF (12 mL) were stirred at 50° C. for 30 min. The mixture was cooled and partitioned between ethyl acetate and water. The organic layer was washed with water (2 times) and brine, dried (Na2SO4) and evaporated in vacuo. The residue was purified by chromatography on silica (chloroform) to give the title compound as an oil:

1. temperatureThe mixture was cooled
2. custompartitioned between ethyl acetate and water
3. washThe organic layer was washed with water (2 times) and brine
4. dry with materialdried (Na2SO4)
5. customevaporated in vacuo
6. customThe residue was purified by chromatography on silica (chloroform)