Sodium hydrosulfide → HCID 178508658, compound

HRID 842717Notes

Reaction equation

HRID 842717 reaction equation
Br[C:2]1[N:3]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([N:10]=1)=[C:8]([NH2:11])[N:7]=[CH:6][N:5]=2.[SH-:19].[Na+]>C(O)C>[CH2:12]([N:3]1[C:2]([SH:19])=[N:10][C:9]2[C:4]1=[N:5][CH:6]=[N:7][C:8]=2[NH2:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 28015Sodium hydrosulfideHCID 99045519-Benzyl-8-bromoadenine

Product 1

HCID 178508658HCID 178508658, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

910 mg (3.0 mmol) of 8-bromo-9-benzyladenine and 1.08 g of sodium hydrosulfide were added to 50 ml of ethanol and heated for 12 hr under refluxing. After the solvent was removed by distillation, the reaction product was dissolved in distilled water and neutralized with 1 N hydrochloric acid. Deposited crystals were collected by filtration to thereby obtain the captioned compound (770 mg; yield: 99%).

Workup

  1. temperatureheated for 12 hr
  2. temperatureunder refluxing
  3. customAfter the solvent was removed by distillation
  4. dissolutionthe reaction product was dissolved in distilled water and neutralized with 1 N hydrochloric acid
  5. filtrationDeposited crystals were collected by filtration
  6. customto thereby obtain the captioned compound (770 mg; yield: 99%)

Sources & evidence

ORD record
ord-b9fd250d3ceb4489b9c275bd3a1a07ee
Source dataset
uspto-grants-2002_04
Patent number
US06376501B1

Reaction notes

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