tert-Butyl 5-bromothiophene-2-carboxylate → 5-(3-Benzyloxycarbonylamino-prop-1-ynyl)-thiophene-2-carboxylic acid tert-butyl ester

HRID 842738Notes

Reaction equation

HRID 842738 reaction equation
[CH2:1]([O:8][C:9](=[O:14])[NH:10][CH2:11][C:12]#[CH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15]([O:19][C:20]([C:22]1[S:23][C:24](Br)=[CH:25][CH:26]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([C:22]1[S:23][C:24]([C:13]#[C:12][CH2:11][NH:10][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:14])=[CH:25][CH:26]=1)=[O:21])([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 10912335tert-Butyl 5-bromothiophene-2-carboxylateHCID 11137906Benzyl prop-2-yn-1-ylcarbamate

Product 1

HCID 545289645-(3-Benzyloxycarbonylamino-prop-1-ynyl)-thiophene-2-carboxylic acid tert-butyl ester

Procedure

The title compound of Step B was prepared from prop-2-ynyl-carbamic acid benzyl ester and 5-bromo-thiophene-2-carboxylic acid tert-butyl ester in an analagous manner to Step A of Preparation 2.

Sources & evidence

ORD record
ord-cf685f3ea09c482aa35952ad6d707ee5
Source dataset
uspto-grants-2002_04
Patent number
US06376502B1

Reaction notes

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