Methyl 5-bromofuran-2-carboxylate → Methyl 5-(3-((tert-butoxycarbonyl)amino)prop-1-yn-1-yl)furan-2-carboxylate

HRID 842740Notes

Reaction equation

HRID 842740 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7](Br)=[CH:8][CH:9]=1)=[O:4].[C:11]([O:15][C:16](=[O:21])[NH:17][CH2:18][C:19]#[CH:20])([CH3:14])([CH3:13])[CH3:12]>>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([C:20]#[C:19][CH2:18][NH:17][C:16]([O:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:21])=[CH:8][CH:9]=1)=[O:4]

Participants

3

Reactant 2

HCID 599633Methyl 5-bromofuran-2-carboxylateHCID 11073648tert-butyl N-(prop-2-yn-1-yl)carbamate

Product 1

HCID 53793873Methyl 5-(3-((tert-butoxycarbonyl)amino)prop-1-yn-1-yl)furan-2-carboxylate

Procedure

The title compound of Step A was prepared from 5-bromo-furan-2-carboxylic acid methyl ester and prop-2-ynyl-carbamic acid tert-butyl ester as described in Step A of Preparation 2.

Workup

  1. customas described in Step A of Preparation 2

Sources & evidence

ORD record
ord-0ef005a91f5d4352b8a7cf124402989d
Source dataset
uspto-grants-2002_04
Patent number
US06376502B1

Reaction notes

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