Potassium Carbonate → HCID 18680648, compound

Chloromethyl ethyl ether (125 g, 1.32 mole) was added dropwise over 1.5 hours to an ice-cooled, stirred suspension of 1,2,3-triazole (91.4 g, 1.32 mole) and anhydrous potassium carbonate (183 g, 1.32 mole) in acetone (1.5 l). The mixture was then allowed to warm to room temperature and stirred for a further 18 hours. The solvent was evaporated under reduced pressure, the residue dissolved in water (1 l) and the aqueous solution extracted with dichloromethane (3×300 ml). The combined extracts were washed with saturated brine (3×300 ml), dried (Na2SO4) and evaporated under reduced pressure to furnish a pale yellow oil.

1. temperaturecooled
2. stirringstirred for a further 18 hours
3. customThe solvent was evaporated under reduced pressure
4. dissolutionthe residue dissolved in water (1 l)
5. extractionthe aqueous solution extracted with dichloromethane (3×300 ml)
6. washThe combined extracts were washed with saturated brine (3×300 ml)
7. dry with materialdried (Na2SO4)
8. customevaporated under reduced pressure
9. customto furnish a pale yellow oil

ORD record

ord-f35c656ebf4143038d69402504d19db0

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06376526B1