Hydrochloric Acid → HCID 86671972, compound

HRID 84315Notes

Reaction equation

HRID 84315 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]([CH2:17][CH2:18][C:19]([CH3:34])([S:30]([CH3:33])(=[O:32])=[O:31])[C:20]([NH:22][O:23]C3CCCCO3)=[O:21])[C:13](=[O:35])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)Cl.O.Cl>O1CCOCC1>[CH:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]([CH2:17][CH2:18][C:19]([CH3:34])([S:30]([CH3:33])(=[O:32])=[O:31])[C:20]([NH:22][OH:23])=[O:21])[C:13](=[O:35])[CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6344DichloromethaneHCID 866719714-[4-(3-cyclohexylpropoxy)-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Product 1

HCID 86671972HCID 86671972, compoundYield 54.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4-[4-(3-Cyclohexylpropoxy)-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (220 mg, 0.429 mmole) was dissolved in dioxane (4 ml), DCM (4 ml) and water (2 ml). To this was added a 4.0M solution of HCl in dioxane (1.0 ml, 4.29 mmole) and was stirred at RT for 1 hour. The reaction mixture was concentrated in vacuo and azeoptroped with IPA (2×5 ml) to afford a white solid (100 mg, 54.4%). MS (LC/MS) m/z 429.1 (M+1) 1H NMR (400 MHz, METHANOL-d4) δ ppm 0.83-1.06 (m, 3 H) 1.19-1.40 (m, 6 H) 1.41 (s, 2 H) 1.64-1.90 (m, 4 H) 2.31-2.41 (m, 1 H) 2.61-2.79 (m, 1 H) 3.08 (s, 3 H) 3.60 (s, 1 H) 3.63-3.71 (m, 1 H) 3.86-3.99 (m, 2 H) 4.04 (s, 1 H) 4.11 (d, J=8.00 Hz, 3 H) 4.25-4.41 (m, 1 H) 6.29 (s, 1 H) 6.53-6.68 (m, 1 H) 7.83-7.93 (m, 1 H)

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo and azeoptroped with IPA (2×5 ml)

Sources & evidence

ORD record
ord-7e9bbd63d444463e9341c12dc69ef61f
Source dataset
uspto-grants-2014_09
Patent number
US08846933B2

Reaction notes

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