HCID 22615024, compound → HCID 54402010, compound

HRID 843184Notes

Reaction equation

C(OC([N:8]([CH2:26][C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1)[CH2:9][CH2:10][CH2:11][O:12][C:13]1[C:18]2[C:19]([CH3:25])=[C:20]([C:22]([OH:24])=O)[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.[NH2:33][NH2:34].[C:35]([OH:43])(=O)[C:36]1[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=1>>[CH3:25][C:19]1[C:18]2[C:13]([O:12][CH2:11][CH2:10][CH2:9][NH:8][CH2:26][C:27]3[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=3)=[CH:14][CH:15]=[CH:16][C:17]=2[O:21][C:20]=1[C:22]([NH:33][NH:34][C:35](=[O:43])[C:36]1[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=1)=[O:24]

Participants

Reactant 2

HCID 22615024HCID 22615024, compound

HCID 68834549HCID 68834549, compound

Product 1

HCID 54402010HCID 54402010, compound

Procedure

This compound was prepared from 4-[3-(tert-butoxycarbonyl-pyridin-3-ylmethyl-amino)-propoxy]-3-methyl-benzofuran-2-carboxylic acid (Example 139-a) and isonicotinic acid hydrazine in a similar manner to Example 139-b and 139-c. Yellow solid. ESI-MS: m/z 460 (MH+), 1H-NMR (CD3OD) δ: 2.11 (2H, tt, J=5.8, 7.3 Hz), 2.66 (3H, s), 2.90 (2H, t, J=7.3 Hz), 3.89 (2H, s), 4.21 (2H, t, J=5.8 Hz), 6.78 (1H, d, J=7.9 Hz), 7.13 (1H, d, J=8.6 Hz), 7.37 (2H, m), 7.86 (1H, m), 7.89 (2H, dd, J=1.7, 4.5 Hz), 8.43 (1H, m), 8.54 (1H, m), 8.74 (2H, dd, J=1.7, 4.5 Hz).

Sources & evidence

ORD record: ord-ae8a89aa31b2451991d9aa3f619f559f
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06376491B1

Reaction notes

Loading…