反应详情

To a solution of sodium salt of mono-tert-butyl malonate (20.4 g) prepared according to the same procedure as in Example 4, bicyclo[2,2,2]oct-5-ene-2-carbonyl chloride (17.1 g) obtained in Preparation Example 2 is slowly added, and the reaction mixture is reacted at −20° C. in a nitrogen atmosphere for 1 hour, and further reacted at 40° C. for 6 hours. Then, the mixture is worked up as in the procedure of Example 1, to obtain 25 g of the pure title compound (purity: 99%, yield: 84%).

1. customobtained in Preparation Example 2
2. additionis slowly added
3. customthe reaction mixture is reacted at −20° C. in a nitrogen atmosphere for 1 hour
4. customfurther reacted at 40° C. for 6 hours