1-Bromopropane → 2-Propylthio-5,6-dimethylbenzimidazole

HRID 843226Notes

Reaction equation

HRID 843226 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([CH3:11])[C:8]([CH3:12])=[CH:7][C:5]=2[N:6]=1.[CH2:13](Br)[CH2:14][CH3:15].[OH-].[Na+].C(OC(=O)C)C>CCCCCC>[CH2:13]([S:1][C:2]1[NH:6][C:5]2[CH:7]=[C:8]([CH3:12])[C:9]([CH3:11])=[CH:10][C:4]=2[N:3]=1)[CH2:14][CH3:15]

Participants

6

Reactant 4

HCID 78401-BromopropaneHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 178422342HCID 178422342, compound

Product 1

HCID 23110262-Propylthio-5,6-dimethylbenzimidazole

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

2-Propylthio-5,6-dimethylbenzimidazole (II) was prepared by the same procedure for I from 0,89 g (0,005 mol) 2-mercapto-5,6-dimethyl-benzimidazole, 0,8 g (0,006 mol) propylbromide in the presence 0,24 g (0,006 mol) sodium hydroxide in a yield of 0,72 g (60%), m.p. 122-123° C. (from mixture ethylacetate with hexane).

Sources & evidence

ORD record
ord-501560c16afc41feacfb60b093a2128b
Source dataset
uspto-grants-2002_04
Patent number
US06376666B1

Reaction notes

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