Ethanol → HCID 22617016, compound

HRID 843251Notes

Reaction equation

HRID 843251 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]2C(=O)C3=CC=CC=C3C2=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(O)C.O.NN>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH2:16])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 22617021HCID 22617021, compound

Product 1

HCID 22617016HCID 22617016, compoundYield 119.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Then, 4.0 g (10.2 mmol) of 1-(4-chlorophenylsulfonyl)-5-phthalimidopentane was dissolved in 120 ml of dichloromethane and 20 ml of ethanol and stirred together with 6 ml of 80% hydrazine hydrate at room temperature for 36 hours. The impurities were filtered out, and the filtrate was evaporated in vacuo to give 3.2 g of the title compound.

Workup

  1. filtrationThe impurities were filtered out
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-21ea75f323e84e46a47f53883b949ce6
Source dataset
uspto-grants-2002_04
Patent number
US06376671B1

Reaction notes

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