Ammonia → HCID 178512062, compound

HRID 843364Notes

Reaction equation

HRID 843364 reaction equation
[NH3:1].[Cl:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([Cl:13])[C:4]=1[N:14]=[C:15](Cl)[C:16]([F:22])([F:21])[C:17]([F:20])([F:19])[F:18]>C(O)C>[Cl:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([Cl:13])[C:4]=1[NH:14][C:15](=[NH:1])[C:16]([F:22])([F:21])[C:17]([F:20])([F:19])[F:18]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22617181HCID 22617181, compound

Product 1

HCID 178512062HCID 178512062, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 40 ml of ethanol and 10 ml of 28% aqueous ammonia was added 3.9 g (10.0 mmol) of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,3,3,3-pentafluoropropionimidoyl chloride, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated, and water was poured into the residue, which was then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to give 3.70 g of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,3,3,3-pentafluoropropionamidine (hereinafter referred to as present compound 4).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was poured into the residue, which
  3. extractionwas then extracted with ethyl acetate
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2f8b2ac619314c109aa6040bf746a000
Source dataset
uspto-grants-2002_04
Patent number
US06376710B2

Reaction notes

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