Dichloromethane → HCID 22617181, compound

HRID 843372Notes

Reaction equation

HRID 843372 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][C:14](=O)[C:15]([F:21])([F:20])[C:16]([F:19])([F:18])[F:17].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:42]CCl>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]=[C:14]([Cl:42])[C:15]([F:21])([F:20])[C:16]([F:19])([F:18])[F:17]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 22617165HCID 22617165, compound

Product 1

HCID 22617181HCID 22617181, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

First, 4.3 g (11 mmol) of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,3,3,3-pentafluoropropionamide was dissolved in 22 ml of dichloromethane, to which 1.8 ml of carbon tetrachloride and 4.5 g (17 mmol) of triphenylphosphine were added at room temperature, and the mixture was stirred for 18 hours. The reaction mixture was concentrated under reduced pressure, followed by addition of hexane, and undissolved matter was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 3.8 g of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,3,3,3-pentafluoropropionimidoyl chloride.

Workup

  1. additionwere added at room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionfollowed by addition of hexane, and undissolved matter
  4. customwas removed by filtration
  5. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d04ddabd37454f45afeeafed5cc88208
Source dataset
uspto-grants-2002_04
Patent number
US06376710B2

Reaction notes

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