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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 843401Generated: October 30, 2026

Trifluoroacetic acid → HCID 131723200, compound

https://huagongshe.com/reaction/843401

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 131723199HCID 131723199—
SolventDichloromethaneHCID 6344—
ProductHCID 131723200HCID 131723200110.4%

Reaction Steps

Methyl 2-{N-methyl-N-[(R/S)-α-t-butoxycarbonylmethyl-4-(3,5-bistrifluoromethylbenzyloxy)phenylacetyl]amino}-(R)-propionate 48e (1.46 g, 2.47 mmol) was treated with 50% TFA in CH2Cl2 (20 mL) for 1 hour and the solution was concentrated in vacuo to give the acid (1.46 g, 100%) as a syrup. MS (ESI): (M+H)+=535.9.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06376665B1
Source datasetuspto-grants-2002_04
ORD IDord-425ac29c3e2a4bdfa67f98c794c86548
Source noteuspto-grants-2002_04