Trifluoroacetic acid → HCID 131723200, compound

HRID 843401Notes

Reaction equation

HRID 843401 reaction equation
[CH3:1][N:2]([C@H:36]([CH3:41])[C:37]([O:39][CH3:40])=[O:38])[C:3](=[O:35])[CH:4]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=2)=[CH:15][CH:14]=1)[CH2:5][C:6]([O:8]C(C)(C)C)=[O:7].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][N:2]([C@H:36]([CH3:41])[C:37]([O:39][CH3:40])=[O:38])[C:3](=[O:35])[CH:4]([C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][C:21]2[CH:22]=[C:23]([C:31]([F:33])([F:34])[F:32])[CH:24]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:26]=2)=[CH:17][CH:18]=1)[CH2:5][C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131723199HCID 131723199, compound

Product 1

HCID 131723200HCID 131723200, compoundYield 110.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl 2-{N-methyl-N-[(R/S)-α-t-butoxycarbonylmethyl-4-(3,5-bistrifluoromethylbenzyloxy)phenylacetyl]amino}-(R)-propionate 48e (1.46 g, 2.47 mmol) was treated with 50% TFA in CH2Cl2 (20 mL) for 1 hour and the solution was concentrated in vacuo to give the acid (1.46 g, 100%) as a syrup. MS (ESI): (M+H)+=535.9.

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-425ac29c3e2a4bdfa67f98c794c86548
Source dataset
uspto-grants-2002_04
Patent number
US06376665B1

Reaction notes

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