Hydrochloric Acid → HCID 57290442, compound

HRID 843428Notes

Reaction equation

HRID 843428 reaction equation
C(OC([N:8]1[CH2:13][C@H:12]([O:14][CH2:15][C:16]2[CH:25]=[C:24]([O:26][CH3:27])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=2)[C@@H:11]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][CH2:37][O:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[N+:45]([O-:47])=[O:46])=[CH:30][CH:29]=2)[C@H:10]([O:48][CH2:49][C@H:50]([OH:57])[CH2:51][N:52]2[CH:56]=[CH:55][N:54]=[CH:53]2)[CH2:9]1)=O)(C)(C)C.Cl>CO>[N:52]1([CH2:51][C@@H:50]([OH:57])[CH2:49][O:48][C@H:10]2[C@H:11]([C:28]3[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][CH2:37][O:38][C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=4[N+:45]([O-:47])=[O:46])=[CH:30][CH:29]=3)[C@@H:12]([O:14][CH2:15][C:16]3[CH:25]=[C:24]([O:26][CH3:27])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH2:13][NH:8][CH2:9]2)[CH:56]=[CH:55][N:54]=[CH:53]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67219697HCID 67219697, compound

Product 1

HCID 57290442HCID 57290442, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to the procedure described in example 1) (1) the (3S,4R,5R)-3-[(2R)-2-hydroxy-3-imidazol-1-yl-propoxy)-5-(4-methoxy-naphthalen-2-ylmethoxy)-4-[4-[3-(2-nitro-phenoxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester was deprotected with HCl in methanol to yield the (R)-1-imidazol-1-yl-3-[(3S,4R,5R)-5-(4-methoxy-naphthalen-2-ylmethoxy)-4-[4-[3-(2-nitro-phenoxy)-propoxy]-phenyl]-piperidin-3-yloxy]-propan-2-ol as colorless foam; MS: 683 (M+H)+.

Sources & evidence

ORD record
ord-de6b0052ec52407da435a6b19d9f1f14
Source dataset
uspto-grants-2002_04
Patent number
US06376672B1

Reaction notes

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