p-Fluoronitrobenzene → HCID 14495277, compound

HRID 843490Notes

Reaction equation

HRID 843490 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH:11]1([NH2:14])[CH2:13][CH2:12]1>>[CH:11]1([NH:14][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 69828Cyclopropylamine

Product 1

HCID 14495277HCID 14495277, compound

Procedure

1-Fluoro-4-nitrobenzene (3.5 g, 24.8 mmoles) is refluxed for 5 hours with 8.1 g (0.14 moles) of cyclopropylamine. After that, the reaction product is poured onto 250 g of ice/water and the precipitate is filtered off. After recrystallization from ethanol, a yellow solid with a melting point of 126°-128° C. is obtained.

Workup

  1. filtrationthe precipitate is filtered off
  2. customAfter recrystallization from ethanol
  3. customa yellow solid with a melting point of 126°-128° C. is obtained

Sources & evidence

ORD record
ord-7f76bc0ac8c84db88d768302fccc7b9e
Source dataset
uspto-grants-2002_04
Patent number
US06379400B1

Reaction notes

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