Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 15789288, compound

HRID 843492Notes

Reaction equation

HRID 843492 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].[CH:12]1([NH2:15])[CH2:14][CH2:13]1>>[CH:12]1([NH:15][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[CH3:11])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 69828Cyclopropylamine

Product 1

HCID 15789288HCID 15789288, compound

Procedure

1-Fluoro-2-methyl-4-nitrobenzene (3.7 g, 24.8 mmoles) is refluxed for 5 hours with 8.1 g (0.14 moles) of cyclopropylamine. After that, the reaction product is poured onto 250 g of ice/water and the solid obtained is recrystallized from ethanol. A yellow solid with a melting point of 35°-37° C. is obtained.

Workup

  1. customthe solid obtained
  2. customis recrystallized from ethanol
  3. customA yellow solid with a melting point of 35°-37° C. is obtained

Sources & evidence

ORD record
ord-ba31133c86f34f85b5c9f83a15e69919
Source dataset
uspto-grants-2002_04
Patent number
US06379400B1

Reaction notes

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