Benzylamine → HCID 178507982, compound

Participants

Reaction Steps

2.7 ml of benzylamine is added to a solution of 5.0 g of the 2,4-dichloro-5-nitropyrimidine (Reference Example 1) in 75 ml of dichloromethane at 5° C., and the solution is stirred for 1 hour. 3.6 ml of triethylamine is added to the solution at 5t, stirred for 10 minutes, washed with 150 ml of saturated sodium bicarbonate, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 6.6 g of the title compound.

Provenance & Evidence