Benzylamine → HCID 178507982, compound

HRID 843651Notes

Reaction equation

HRID 843651 reaction equation
[CH2:1](N)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[N:15]=[C:14](Cl)[C:13]([N+:17]([O-:19])=[O:18])=[CH:12][N:11]=1.C([N:22](CC)CC)C>ClCCl>[CH2:1]([C:12]1[C:13]([N+:17]([O-:19])=[O:18])=[CH:14][NH:15][C:10]([Cl:9])([NH2:22])[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7504BenzylamineHCID 8471TriethylamineHCID 5212662,4-Dichloro-5-nitropyrimidine

Product 1

HCID 178507982HCID 178507982, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.7 ml of benzylamine is added to a solution of 5.0 g of the 2,4-dichloro-5-nitropyrimidine (Reference Example 1) in 75 ml of dichloromethane at 5° C., and the solution is stirred for 1 hour. 3.6 ml of triethylamine is added to the solution at 5t, stirred for 10 minutes, washed with 150 ml of saturated sodium bicarbonate, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 6.6 g of the title compound.

Workup

  1. stirringstirred for 10 minutes
  2. washwashed with 150 ml of saturated sodium bicarbonate
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3bddb5ea96dd429cb298709d54580e79
Source dataset
uspto-grants-2002_04
Patent number
US06380206B1

Reaction notes

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