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HRID843728

反应详情

EQUATION

反应方程式

HRID 843728 的结构方程式

REACTANTS

反应物

2
反应SMILES：C=O
HCID712

Formaldehyde

CH2O

反应SMILES：C[Si](C)(C)C#CC1CC(=O)N1
HCID10103534

未命名化合物

PRODUCTS

产物

1
反应SMILES：C[Si](C)(C)C#CC1CC(=O)N1CO
HCID11816448

未命名化合物

收率 75%

PROCEDURE

实验过程

4-(2-Trimethylsilylethynyl)-2-azetidinone (485 g) and paraformaldehyde (261 g) was heated at 135° C. for 45 minutes. The resulting mixture was cooled to room temperature and purified with column chromatography on silica gel (CH2Cl2: EtOAc=8:2) to give N-hydroxymethyl-4-(2-trimethylsilylethynyl)-2-azetidinone (429 g).

WORKUP

后处理

  1. custompurified with column chromatography on silica gel (CH2Cl2: EtOAc=8:2)