HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 11816448, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 10103534 | HCID 10103534 | — |
| Product | HCID 11816448 | HCID 11816448 | 75% |
Reaction Steps
4-(2-Trimethylsilylethynyl)-2-azetidinone (485 g) and paraformaldehyde (261 g) was heated at 135° C. for 45 minutes. The resulting mixture was cooled to room temperature and purified with column chromatography on silica gel (CH2Cl2: EtOAc=8:2) to give N-hydroxymethyl-4-(2-trimethylsilylethynyl)-2-azetidinone (429 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380215B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-be3c765315c3464a99390f2dad680c0f |
| Source note | uspto-grants-2002_04 |